Why the discovery of new cancer treatments is booming


Five Years After the First FDA Approval of Chimeric Antigen Receptor (CAR) T-Cell Therapy, Penn Medicines Collects 20 Additional Approvals Related to Drugs and Technologies for the Treatment or Detection of Cancer rice field.

“Cancer”, as many people refer to it, is not a single disease class but an umbrella term that encompasses more than 100 different diseases, many of which are common except that they arise from rapidly dividing cells. There are very few points. Different cancers require different treatments, so any new treatment emerging from any institution is likely to be a new cancer treatment.

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Image: Pen Medicine News

But why have there been so many in the last five years alone?

Robert Vonderheid, director of the Abramson Cancer Center (ACC), said the volume of new cancer drugs was natural, adding that the wave of approvals for new cancer drugs was part of the recent “explosion of knowledge” about cancer biology. It is said that it is due to

“Much of that knowledge is about the immune system’s ability to attack cancer, but people seriously questioned this ability until about 20 years ago. Clinical validation of this Achilles heel in cancer is complete.” I quickly had ideas for other ways to exploit the vulnerability,” he says. “The first drug that came out to boost the immune system inspired other fields to find the next drug. I have moved.”

The first approval of CAR T-cell therapy has galvanized faculty at the University of Pennsylvania interested in discovering new ways to harness the immune system to fight cancer.

“Having that kind of approval makes what we’re doing a lot more real,” says Avery Posey, assistant professor of systems pharmacology and translational therapy at Perelman College of Medicine. His research team spends a lot of time identifying more studies. We are investigating antigens specific to solid tumors and how to optimize engineered donor T cells. “This brings a new perspective and shows that your research can be more than just basic research, it can be medicine that actually impacts the lives of patients. increase.”

Polishing new immunotherapies is a priority for researchers at the University of Pennsylvania, but not all of the recently approved new cancer treatments and detection tools developed at the institution involve the immune system. do not have. Faculty members have explored and implemented a wide variety of approaches to improve the standard of care for cancer patients.

Read full text Pen medical journal.



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