Time of day may be important for diagnosis and treatment


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Researchers show that a person’s circadian rhythm can influence the effectiveness of certain drugs. Vera Rea/Stocksey
  • The body’s circadian rhythms help ensure that the body goes through all the natural processes it needs to occur on a 24-hour cycle.
  • Previous research has shown that circadian rhythms can influence the effectiveness of certain health conditions and medications.
  • Researchers at the Swiss Federal Institute of Technology have found that circadian rhythms can also influence the success of cancer diagnosis and treatment.

Your body’s circadian rhythm (the natural 24-hour cycle that occurs throughout the day) affects your sleep.

However, previous research has also found that circadian rhythms influence many health concerns. mental disorder, epilepsy, cardiovascular diseaseand Diabetes.

An April 2021 study found that a person’s circadian rhythm can affect the effectiveness of certain drugs depending on what time of day they are administered.

Researchers at the Swiss Federal Institute of Technology (ETH) Zurich now believe that circadian rhythms may also influence the success of cancer diagnosis and treatment.

This study was recently published in the journal Trends in cell biology.

Your circadian rhythm is basically your body’s master clock.

Every day, the body goes through a series of processes that last about 24 hours. This includes physical, behavioral and mental changes. hormonal activity and digestionCircadian rhythms ensure that your body goes through these processes.

Circadian rhythms also regulate the body sleepy/arousal cycleDuring the day, our circadian rhythm keeps us awake and alert. At night, it helps your body rest through sleep.

Certain things can disrupt your body’s natural circadian rhythms, such as:

When a person’s circadian rhythm is disturbed, it can become a circadian rhythm sleep disorder.

and previous research In mice, circadian rhythm disruption is associated with cancer development.

In this study, the research team analyzed the current data known about circadian rhythms and cancer development, diagnosis, and treatment.

scientists discovered that metastasis — the spread of cancer cells from their original site to other parts of the body — associated with circadian rhythms.

For example, the authors say breast cancer is likely to metastasize. At night Prostate cancer is more likely to metastasize while a person is asleep at other times during the day.

The authors believe that a person’s circadian rhythm may influence the efficacy of chemotherapy and immunotherapy.a process called Chronotherapy It can be used to regulate the body’s circadian rhythm and treatment delivery.

Researchers also found that the time of day cancer treatment is received can influence the success rate of cancer treatment.

Scientists learn in 2021 Melanoma patients who received immunotherapy before 4:30 p.m. had almost twice the survival rate compared to those treated later in the day.

The research team reported that circadian rhythms may help doctors diagnose cancer.

like cancer cells make protein Researchers believe that knowing when these proteins are at their highest levels at different times of the day will reduce misdiagnosis and aid in biopsies.

After reviewing this study, he is a Neuro-Oncologist and Director of Neuro-Oncology at Providence St. John’s Health Center and Chief of Translational Neuroscience and Neurotherapy Division at St. John’s Cancer Institute in Santa Monica, California. , and regional healthcare provider, Dr. Santosh Kesari, said: The director of the Providence Southern California Institute of Research and Clinical Research said this is a new concept that is not yet well understood.

Dr Kesari, who was not involved in the study, said: medical news today Nevertheless:

“[B]Based on various preclinical data, and perhaps some clinical data, circadian rhythms can clearly influence not only sleep and other functions but also many biology related to cancer development and treatment. It looks like there is. We’ll look at how cancer and circadian rhythms affect the effectiveness of different treatments (immunotherapy and chemotherapy) in patients. “

Manmeet S. Ahluwalia, Ph.D., Associate Director, Chief Scientific Officer, Chief of Medical Oncology, Fernandez Family Foundation Endowment Chair, Miami Cancer Institute, Miami Cancer Institute, was not involved in this study, nor was involved in this study. to arguments that are not even involved.

If this concept is validated in a prospective setting, it may, in the future, help physicians recommend treatments at specific times to increase efficacy or minimize side effects.

“For example, in patients with ovarian cancer, Adriamycin morning and Cisplatin Patients who received adriamycin in the evening and cisplatin in the morning had fewer side effects than those who received it,” he noted.

Both doctors agreed that additional research on this topic is needed before any major changes are adopted.

“Because the findings may have far-reaching implications for how cancer patients are treated, studies related to circadian rhythms use embedded translational research to support clinical findings. It would be great if we could do this and validate it in a future clinical setting,” Dr. Alwalia said.

Dr. Kesari cautioned that studying the effects of circadian rhythms on cancer development in humans may be difficult because cancers take years to develop in the body.

Still “I think there is [are] Several mouse models that can be studied to confirm disruption [the] Circadian rhythms and what they tend to be,” he added.

Regarding the influence of circadian rhythm in cancer treatment, Dr. Kesari said it is very important.

“The question is the size of the effect and whether it’s worth altering whether you treat in the morning, afternoon, or evening based on your circadian rhythm,” he emphasized.

“I think there is still a lot to learn. It is obviously difficult to apply to humans, especially since clinics are open from 8am to 5pm or 6pm. , it’s not easy to get the timing right in that situation.Clearly, it’s much easier to have oral chemotherapy or oral treatment at specific times.”
— Dr. Santosh Kesari



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