The Best Treatment for Excessive Daytime Sleepiness — ScienceDaily


McMaster University researchers Dena Zerertkar and Tyler Pitre find soluriamfetol the most effective treatment for excessive daytime sleepiness (EDS) in patients with obstructive sleep apnea (OSA) found to be relevant.

The standard treatment for OSA is a positive airway pressure (PAP) mask that uses compressed air to support the airways of your lungs while you sleep. However, some patients with OSA still experience EDS and may benefit from anti-fatigue medications.

Zeraatkar and Pitre present the results Annals of Internal Medicine.

“The most important thing for people with OSA to do is use a PAP machine, but if they’re still sleepy, there are options in the form of medications that can reduce fatigue,” says lead author Tyler Pitre, an internal medicine resident. said Mr. He holds a PhD from McMaster University and plans to become a respiratory research fellow at the University of Toronto.

“With 15-30% of the population diagnosed with OSA in North America, and many others undiagnosed, the prevalence may be even higher. The condition is highly associated with obesity. Because of the spread of the disease, many people have symptoms, and more and more people are affected by it, “people in Canada, the United States and other high-income countries,” he said.

“Many of these patients have EDS, which affects their quality of life, reduces their productivity, and puts them at risk for other psychological problems. Most important.”

Pitre said OSA affects about 1 billion people worldwide, many of whom are at risk of EDS.

Zeraatkar and Pitre conducted a systematic review of 14 clinical trials of anti-fatigue drugs involving 3,085 participants and analyzed data from MEDLINE, CENTRAL, EMBASE and ClinicalTrials.gov in a specific network meta-analysis. We made that discovery by doing so. They conducted the survey from October 2022 to January 2023.

Lead author Zeraatkar said that soluriamfetol is likely the best treatment for EDS, but the drugs armodafinil/modafinil and pitrisant are also effective in fighting fatigue.

Soulimfetol can also raise blood pressure, which is especially dangerous for OSA patients because many of them also have cardiovascular problems.

“It will be interesting to see how effective these anti-fatigue drugs are in treating chronic fatigue syndrome and related diseases such as long-term COVID-19,” said Zerathkar, an assistant professor at the department. “We know that drugs are effective for similar symptoms.” of anesthesia.



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