New Clinical Guidelines to Support Women After Surgery to Reduce Ovarian Cancer Risk



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Image credits: Becca Tapert, Unsplash

The first evidence-based clinical guideline for managing women’s health before and after surgery to reduce the risk of ovarian cancer has been developed by an international team of researchers to achieve better health and well-being outcomes for women. It offers.

Posted in International Journal of Obstetrics and Gynecologya scoping review provides new recommendations to support women at high risk of developing ovarian cancer undergoing risk-reducing salpingo-oophorectomy (RRSO) surgery.

RRSO surgery, which removes the fallopian tubes and ovaries in women with a BRCA1/2 pathogenic variant to reduce the risk of ovarian cancer, has many short- and long-term health implications for women. can have adverse effects in some way.

Lead author Professor Martha Hickey, Chair of Obstetrics and Gynecology at the Royal Women’s Hospital, found that 1 in 450 women carry a BRCA1/2 variant, and the number of women considering RRSO surgery is 1 in 450. said to be increasing.

“RRSO can be offered premenopausally to women at high risk of ovarian cancer. Although potentially lifesaving, RRSO can adversely affect quality of life and is a condition that compromises long-term health.” ,” said Professor Hickey.

“Despite the efficacy of RRSO to reduce the risk of ovarian cancer, the procedure causes permanent infertility and is associated with menopause, mood and sleep disturbances, sexual difficulties, osteoporosis and cardiovascular disease. It can cause an increased risk of long-term health problems.”

Professor Hickey and his team conducted an extensive scoping review and developed the first international consensus clinical guidelines for managing high-risk women before and after RRSO, from preoperative counseling to long-term disease prevention. bottom.

Professor Hickey said the guidelines will lead to better health for these women.

“We recommend informing women of these possible effects before surgery and taking the opportunity to discuss available treatments after RRSO. Clinicians develop an individualized plan for postoperative care. You have to,” said Professor Hickey.

“By effectively reducing the risk of ovarian cancer, these women should be able to live longer, healthier lives. It’s an important aspect.”

New recommendations include::

  • Counseling before undergoing RRSO surgery
  • Discussion of the advantages and disadvantages of concurrent hysterectomy during RRSO
  • Management of vasomotor symptoms – hot flashes and night sweats – after RRSO in women, including women with breast cancer
  • Safe and effective treatment of vasomotor symptoms
  • Active management of sleep and mood disorders after RRSO
  • Management of sexual and genitourinary symptoms after RRSO
  • Lifestyle and pharmacological interventions to prevent cardiovascular and bone disease after RRSO



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