Mindfulness, self-compassion as an effective Alzheimer’s treatment option

Researchers evaluated the safety and efficacy of online mindfulness and self-compassion in the setting of atopic dermatitis (AD) and whether alternative treatment options are effective to use for chronic skin conditions. I discovered something.

Findings published in JAMA Dermatology Results from a comparison of two randomized patient groups are shown. Her 56 patients in the intervention group received eight of her 90-minute group sessions weekly, and her 51 patients in the control group were placed on a waiting list. In addition, the intervention group had access to a 5.5-hour meditation retreat or her 2-hour Zoom videoconferencing booster session (both optional). The intervention was led by a board-certified clinical psychologist and included mindfulness-based stress reduction and self-compassion.

This randomized clinical trial was conducted between March 2019 and October 2022, and all participants had a Dermatology Life Quality Index (DLQI) score of 6 or higher. DLQI scores range from 0 (disease not life-threatening) to 30 (very life-threatening). large effect), DLQIs were administered at baseline, mid-intervention (week 4), post-intervention (week 9), and 4 weeks later.

The primary outcome of the study was the change in DLQI score from baseline to week 13; included symptoms. Most participants were female patients (79.4%), with a mean (SD) patient age of 36.3 (10.5) years and a mean AD duration of 26.6 (11.7) years.

“Alzheimer’s patients have the lowest reported quality of life among skin disorders,” the study authors wrote. “To our knowledge, mindfulness and self-compassion training has not been evaluated in adults with Alzheimer’s disease.”

Ninety-eight percent of the intervention group completed at least 75% of the 90-minute group sessions during the study period, and 98.1% completed the final study assessment at 13 weeks. Within both groups, at least 54% had a college education, 52% were single or unmarried, 51% worked full-time, and 51% had at least one outpatient visit in her 3 months. reported. Overall, 74.8% reported attending an outpatient dermatology clinic.

The most common dermatological treatment was moisturizer in 76.8% of the intervention group and 76.5% of the waiting list group. Topical steroids 64.3% and 60.8%, respectively. 55.4% and 52.9% are taking antiallergic oral medications.

Intention-to-treat analysis after 13 weeks showed significant improvement in DLQI between intervention and control groups: -6.34 (95% CI, -8.27 to -4.41; P. < .001). Furthermore, quality of life in the intervention group continued to improve throughout the study, whereas in the wait list group it plateaued at week 9 and at week 13 the standardized effect size was -1.06 (95% CI, -1.39 to 1.39). )was. -0.74). A clinically important difference in DLQI scores was seen in 81.5% (95% CI, 68.6% to 90.7%) of the intervention group and 33.3% (95% CI, 20.8% to 47.9%) of the wait list group, with similar It was a week. 13. The intervention group was also more adherent to the treatment plan and more likely to follow the dermatologist's plan.

All secondary outcomes showed significant improvement in the intervention group compared to the wait list group at week 13 (all least squares mean estimates).

  • Patient-oriented eczema measure: 10.64 (95% CI, 8.94-12.35) vs 16.39 (95% CI, 14.63-18.16)
  • Pre-sleep itch intensity: 2.47 (95% CI, 1.83-3.12) vs 4.72 (95% CI, 4.06-5.38)
  • Scratch intensity: 3.14 (95% CI, 2.48-3.79) vs 5.11 (95% CI, 4.43-5.78)
  • Itching annoyance: 2.41 (95% CI, 1.77-3.06) vs 4.49 (95% CI, 3.83-5.15)
  • Freiburg Mindfulness Inventory: 39.06 (95% CI, 37.18-40.94) vs 31.55 (95% CI, 29.60-33.49)
  • Hospital anxiety and depression scale: 4.61 (95% CI, 3.55-5.66) vs 8.16 (95% CI, 7.07-9.24)
  • Internalized shame Shame scale: 31.27 (95% CI, 27.01-35.54) vs 49.22 (95% CI, 44.79-53.64)
  • Internalized shame measure self-esteem: 15.47 (95% CI, 14.26-16.69) vs 11.88 (95% CI, 10.62-13.15)

Only one serious adverse event was reported, which the investigators noted was unrelated to the study intervention: early-stage endometrial cancer diagnosed by surgery before analysis.

“This study is the first, to our knowledge, to show that group-style mindfulness and self-compassion improve quality of life in adults with Alzheimer’s disease,” the study authors concluded. “Combining mindfulness and self-compassion interventions with usual care was able to improve physiological symptoms.”

Still, they believe more research is needed to apply the current findings to a wider audience.

“We understand the importance of detailed pathway analysis of intervention effects, which is within the scope of future studies,” they emphasized.


Tetsuya Kishimoto, Naoya Watanabe, Yuya Yamamoto, et al. Effectiveness of integrated online mindfulness and self-compassion training for adults with atopic dermatitis: a randomized clinical trial. JAMA Dermatol. Published online on May 10, 2023. doi:10.1001/jamadermatol.2023.0975

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