India-led US team finds ‘breakthrough’ cure for brain tumors


India-led US team finds 'breakthrough' cure for brain tumors

The research was published in the latest issue of the scientific journal Nature.

Thiruvananthapuram:

A team of scientists at the University of California, San Francisco Medical Center has made a groundbreaking discovery that could lead to a fundamental change in the treatment of cancerous brain tumors. found to be the cause. Patient’s rapid cognitive loss and death.

The research team, led by Indian Sarisa Krishna, also found that commonly used anti-seizure drugs were effective in reducing tumor cell hyperactivity and even stopping their growth.

The research was published in the latest issue of the scientific journal Nature.

Scientists have discovered that communication between healthy brain cells and cancer cells can be manipulated to slow or even stop tumor growth.

The study notes that these findings are more beneficial for patients with glioblastoma, which is thought to be the deadliest brain tumor in adults.

A study conducted by Ms. Krishna and fellow scientist Sean Harvey Jumper recorded the brain activity of patients undergoing brain tumor surgery in the awake state while the brain tumors hijacked and altered brain circuits to mimic glioma patients. discovered a previously unknown mechanism that causes cognitive decline in .

Ms. Krishna, the lead author of the paper from Thiruvananthapuram, Kerala, said in an interview with PTI that when a patient was given a language task during awake brain surgery, the commonly known language areas of the brain In addition to , activation of the following regions was noted. The tumor-infiltrated brain regions were far from the verbal brain zone.

This unexpected finding suggests that lethal cancer cells can hijack and remodel connections in the surrounding brain tissue, making it hyperactive, accelerating cognitive decline and shortening patient survival. showed that it has potential.

Scientists have therefore used brain organoids—small bundles of neurons derived from mouse models engrafted with human stem cells or human glioblastoma cells—to perform extensive biological characterization of relevant tumor cells. I was forced to implement it.

“These experiments reveal a key role for a protein called ‘thrombospondin-1’ in this neuronal hyperexcitability, and that gabapentin, a commonly used anti-seizure drug, reduces neuronal hyperexcitation. We found that it was successful in suppressing and preventing further tumor growth,” the study cites.

The findings could go a long way toward developing more effective treatments for such deadly diseases as glioblastoma, the scientists said.

“In addition to this known anti-seizure activity, this study using a mouse model to discover gabapentin’s anti-tumor effects highlights the potential for repurposing this existing drug to target tumor growth. , thereby facilitating drug development for patients with malignant glioma,” said Professor Salisa.

In addition, key findings about brain circuit hijacking by cancer cells could lead to the development of drugs and neuromodulatory techniques that can cut neural connections to brain cancer cells and stop tumor growth, he said. added.

“Noninvasive brain modulating techniques, traditionally applied to modulate neuronal function in epilepsy and psychiatric disorders, are now available in clinical trials and tested in brain tumor patients to suppress glioma activity. It is possible that the

(Except for the headline, this article is unedited by NDTV staff and is published from a syndicated feed.)



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