Cancer diagnosis and treatment may be influenced by circadian rhythms


Circadian rhythms govern our sleep schedules, and a new study shows how it can also affect the development, diagnosis and treatment of cancer.ETH Zurich, Switzerland researchers have uncovered how circadian rhythms in tumor progression spread and how patients know when to be tested for cancer and when to receive treatment to improve treatment success. I explained what could be improved.

The survey results are Trends in cell biology In a paper titled “A New Time Dimension in the Fight Against Transference”.

“Despite advances in finding vulnerabilities, identifying biomarkers, and developing more effective therapies, cancer remains a threat because of its ability to develop resistance to treatment and progress. “Since circadian rhythms govern most of the cellular functions involved in cancer progression, their exploitation opens promising new directions in the fight against metastasis.” In this review, we summarize the role of circadian rhythms in tumor development and progression, with an emphasis on circadian rhythm regulatory elements that control circulating tumor cell (CTC) generation and metastasis.”

“Since circadian rhythms govern most of the cellular functions involved in cancer progression, their exploitation opens up new promising directions in the fight against metastasis,” said Zoi, author and molecular oncologist. Dr. Diamantopoulou, Dr. Ana Gvozdenovic, and Nicola Aceto wrote. PhD from ETH Zurich, Switzerland.

Recent studies have shown that circadian rhythms are involved not only in tumor development, but also in cancer progression and metastasis, i.e. colonization of secondary sites in the body.

The authors argue that this information can be used to optimally target tumor cell-targeted chemotherapy and immunotherapy. Giving medications or immunotherapy at specific times of the day is known as chronotherapy.

“Circadian rhythm-based metastasis formation should be viewed as an opportunity to intervene in the most timely and effective manner,” the authors wrote. “Chronotherapy has the potential to be a valuable alternative treatment option in the fight against cancer.”

Clinical studies indicate that chronotherapy may reduce the severity of side effects experienced by patients and may also affect treatment efficacy. A recent study found that melanoma patients who received immunotherapy drugs were nearly twice as likely to survive as those treated later in the day.

“A more mechanistic understanding of these processes will be needed to unlock their full potential clinically,” the authors write. Defining the timing of controlled circulating tumor cell proliferation and release into the bloodstream may help identify the optimal timeframe for therapeutic administration.”



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